砂仁挥发油中乙酸龙脑酯的镇痛作用及其机制研究

目的:研究砂仁挥发油主要成分乙酸龙脑酯的镇痛作用及机制.方法:采用大鼠尾尖压痛实验观察乙酸龙脑酯的镇痛作用;福尔马林实验观察其I相和Ⅱ相疼痛反应;纳洛酮拮抗实验观察对乙酸龙脑酯镇痛作用的影响.结果:乙酸龙脑酯可提高尾尖压痛大鼠的痛阈值;对福尔马林致痛模型动物Ⅰ相和Ⅱ相疼痛反应均有抑制作用;纳洛酮未能显著减弱乙酸龙脑酯的镇痛作用.结论:乙酸龙脑酯具有较显著的镇痛作用;其镇痛作用部位即在外周神经末梢,亦可能在中枢神经;镇痛作用机制可能不同于阿片类药物.

Research on the Analgesic Effect and Mechanism of Bornyl Acetate in Volatile Oil from Amomum Villosum

OBJECTIVE: To study the analgesic effect and mechanism of bornyl acetate, the main ingredient of Amomum Villosum Volatile oil. METHODS: The analgesic effects were tested by pressing tail method. The I, and II phase pain were observed with the pain model caused by formalin test. Influence of naloxone antagonism test on analgesic effect of bornyl acetate. RESULTS: Bornyl acetate produced obvious analgesic effects on pain models induced by pressing tail. Bornyl acetate had inhibitory effect on I and II phase pain in formalin inducing pain model animals. Analgesic effect induced by Bornyl acetate wasn't significantly reduced by naloxone. CONCLUSION: Bornyl acetate shows analgesic effects. The analgesic site may locate in both central and peripheral nervous system. Its analgesic action way not be related to the opioid receptor.