| Human papillomaviruses as targets for cancer gene therapy |
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| 作者姓名： | Poornima Kamath Edward J.Shillitoe Karen Adler-Storthz |
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| 作者单位： | Department of Basic Sciences，Dental Branch，University of Texas at Houston，Department of Microbiology and Immunology，State University of New York，College of Medicine，Department of Basic Sciences，Dental Branch，University of Texas at Houston |
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| 摘 要： | Gene therapy of human cancer is likely to bemost effective when it is directed at targets that areexpressed in cancer cells but are lacking from othercells. Human papillomaviruses (HPV) can providesuch target, since these viruses are present in manycervical and oral cancers, and likely to be etiologicagents of the tumor. The oncogenic ability of HPVhas been assigned primarily to its two early genes, E6and E7. Continued expression of these two genes is
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