肠外与肠内营养联合奥曲肽对胰瘘分泌的影响

目的 :观察 17例胰瘘病人在实施肠外与肠内营养联合奥曲肽对胰瘘分泌的影响。　方法 :观察肠外或经鼻空肠管和空肠造口管的肠内营养支持途径 ,并比较使用奥曲肽前后 1、4、7天胰液分泌、胰液中蛋白量、淀粉酶以及HCO-3 、K 、Na 和Cl-量的变化。　结果 :肠外与肠内营养期间胰液量、胰液中蛋白量、淀粉酶及HCO-3 、K 、Na 和Cl-量两组无明显变化 (P <0 .0 5 ) ;加用奥曲肽后两组均有下降 ,肠外营养加奥曲肽组虽下降幅度稍大于肠内营养加奥曲肽组 ,但未达到统计学意义 (P >0 .0 5 )。　结论 :肠外和经空肠置管的肠内营养没有刺激胰腺分泌和加重胰腺负担 ;若结合奥曲肽 ,则可明显抑制胰液分泌

Effects of parenteral or enteral nutrition combined Octreotide on pancreatic secretion of patients with pancreatic fistula

Objectives:The effects of parenteral and enteral nutrition combined Octreotide on pancreatic secretion of patients with pancreatic fistula were compared. Methods:Pancreatic juice,drained directly from the pancreatic fistula,was collected before and after using Octreotide,and volume,bicarbonate,protein,amylase,HCO - 3,K ,Na and Cl - were measured. Results:No differences in exocrine pancreatic secretion were observed between the enteral and parenteral methods of feeding.There were significant decreases in pancreatic secretion volume,bicarbonate,protein,amylase,HCO - 3,K ,Na and Cl - after using Octreotide( P<0.05). Conclusions:Intrajejunal feeding has no stimulatory effect and is therefore beneficial to the patient with pancreatic fistula.Octreotide is effective in the reduction of pancreatic fistula output.