胰岛细胞肿瘤35例诊治分析

目的探讨胰岛细胞肿瘤的诊断和治疗，对胰岛细胞肿瘤发病情况进行分析。方法回顾性分析1953～2003年浙江大学医学院附属第二医院收治的胰岛细胞肿瘤35例，并结合国内有关文献报道进行诊治分析。结果35例胰岛细胞肿瘤经手术切除病理证实33例，其中胰岛紊瘤24例（72，7％，24／33），无功能胰岛细胞瘤7例（21．2％，7／33），胰高糖素瘤、胃泌素瘤各1例。国内同期文献报道胰岛细胞肿瘤2785例。结论胰岛细胞瘤主要是胰岛素瘤和无功能胰岛细胞瘤，其他肿瘤少见。对良性者宜行单纯肿瘤切除或胰腺部分切除，对恶性肿瘤应采用扩大范围的根治性肿瘤切除术为主的综合治疗，预后好于其他腹腔内脏器肿瘤。

Diagnosis and treatment of pancreatic islet cell tumor:a report of 35 cases

Objective To discuss the diagnosis and treatment of pancreatic islet cell tumor and review its incidence in China based on the recent literatures.Methods Thirty-five patients with pancreatic islet cell tumor from 1953 to 2003 admitted in the 2nd Affilinted Hospital of Zhejiang University School of Medicine were analyzed retrospectively.The diagnosis and treatment of pancreatic islet cell tumor were also discussed based on the recent native literatures.Results Thirty-three patients with pancreatic islet cell tumor received operation,which were confirmed by pathology. Among 33 patients,there were 24 cases classified as insulinoma (72.7%,24/33),7 cases of non-functional pancreatic islet cell tumor (21.2%, 7/33),1 case of glucagonoma and 1 case of gastrinoma.There were 2 785 cases of pancreatic islet cell tumor reported in literature during same period.Conclusion Insulinoma and non-functional pancreatic islet cell tumor are the mostly dominant in pancreatic islet cell tumor.It should be performed simply tumor remove or partial pancreas resection for benign pancreatic islet cell tumor.Extended radical resection combined with other comprehensive treatment is benefited for malignant pancreatic islet cell tumor.It has a better prognosis than other abdominal organ tumors.