Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence |
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Authors: | K Ekdahl J Rollof V A Oxelius J Engellau J H Braconier |
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Institution: | (1) Department of Infectious Diseases, Lund University Hospital, S-22185 Lund, Sweden;(2) Department of Pediatrics, Lund University Hospital, S-22185 Lund, Sweden;(3) Department of Oncology, Lund University Hospital, S-22185 Lund, Sweden |
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Abstract: | In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35 %) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p<0.001), IgG1 (p<0.001), IgG2 (p<0.001), IgG3 (p<0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18 %) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection. |
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