| 摘 要： | AIM:To study morphologic and biomechanical changes ofoesophagus in diabetes rats.METHODS:Diabetes was induced by a single injection ofstreptozotocin(STZ).The type of diabetes mellitusinduced by parenteral STZ administration in rats wasinsulin-dependent(type I).The samples were excisedand studied in vitro using a self-developed biomaterialtest machine.RESULTS:The body mass was decreased after 4 d with STZtreatment.The length of esophagus shortened after 4,7,14 d.The opening angle increased after 14 d.The shear,longitudinal and circumferential stiffness were obviouslyraised after 28 d of STZ treatment.CONCLUSION:The changes of passive biomechanicalproperties reflect intra-structural alteration of tissue to acertain extent.This alteration will lead to some dysfunctionof movement.For example,tension of esophageal wallwill change due to some obstructive disease.
|
