| 肿瘤抗原MAGE-A亚家族共同B细胞表位预测及分析 |
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| 引用本文： | 龙海霞,万瑾,王远强,朱波,倪兵,吴玉章,林治华.肿瘤抗原MAGE-A亚家族共同B细胞表位预测及分析[J].免疫学杂志,2009(5). |
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| 作者姓名： | 龙海霞 万瑾 王远强 朱波 倪兵 吴玉章 林治华 |
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| 作者单位： | 重庆工学院生物工程学院分子设计实验室;第三军医大学新桥医院全军肿瘤研究所;第三军医大学基础部全军免疫学研究所; |
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| 基金项目： | 国家自然科学基金(30471579,30571714);;新世纪优秀人才支持计划项目(NCET-06-0780);;全国博士学位论文作者专项资金资助项目(200776) |
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| 摘 要： | 目的预测肿瘤抗原MAGE-A亚家族的B细胞表位,为基于多靶点的肿瘤疫苗设计提供依据。方法基于MAGE亚家族各成员蛋白质序列,采用Kyte-Doolittle的亲水性方案,Emini方案,Karplus方案和Jameson-wolf抗原指数方案,并辅以MAGE蛋白的二级结构柔性区域分析,预测MAGE基因家族的B细胞共同表位。结果共预测出了5条共同表位,且部分B细胞表位高度相似或一致。结论二级结构与B细胞表位相结合的预测方法为一种高效、准确的表位预测方法,可为肿瘤治疗性疫苗的设计提供实验依据。
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| 关 键 词： | MAGE-A亚家族 二级结构 B细胞表位 |
Prediction of the common B cell epitopes derived from the tumor antigen MAGE-A sub-family |
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| LONG Haixia,WAN Jin,WANG Yuanqiang,ZHU Bo,NI Bing,WU Yuzhang,LIN Zhihua Laboratory of Chemical , Bioengineering,Chongqing Institute of Technology,Chongqing ,China.Prediction of the common B cell epitopes derived from the tumor antigen MAGE-A sub-family[J].Immunological Journal,2009(5). |
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| Authors: | LONG Haixia WAN Jin WANG Yuanqiang ZHU Bo NI Bing WU Yuzhang LIN Zhihua Laboratory of Chemical Bioengineering Chongqing Institute of Technology Chongqing China |
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| Institution: | LONG Haixia,WAN Jin,WANG Yuanqiang,ZHU Bo,NI Bing,WU Yuzhang,LIN Zhihua Laboratory of Chemical , Bioengineering,Chongqing Institute of Technology,Chongqing 400050,China |
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| Abstract: | Objective To predict the B cell epitopes from tumor antigen MAGE-A sub-family,which could be used as the target in tumor immunotherapy.Methods Based on MAGE-A sub-family amino sequence combined with the analysis of the flexible regions of secondary structure of MAGE-A protein,the B cell epitopes of MAGE-A protein were predicted by methods of Kyte-Doolittle hydrophilicity plot,Emini,Karplus,and Jameson-Wolf.Results Five B cell epitopes derived from the tumor antigen MAGE-A sub-family were selected and some o... |
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| Keywords: | MAGE-A sub-family secondary structure B cell epitope |
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