住院患者病原菌分布及耐药性分析

目的了解感染性疾病病原菌分布及常见病原菌的耐药情况。方法对2007年7月至2008年6月住院患者细菌培养和药敏试验的结果进行统计和分析。结果共分离病原菌1189株，其中革兰阳性（G＋）菌372株，占31.3%；革兰阴性（G-）菌817株，占68.7%；主要包括大肠埃希菌（23.5%）、肺炎克雷伯菌（12.4%）、金黄色葡萄球菌（10.3%）等；药敏试验结果显示，所分离的G＋菌对万古霉素、利奈唑胺最敏感，对呋喃妥因、利福平敏感性较好，对其他抗菌药物敏感性不佳，G-菌对亚胺培南高度敏感，对哌拉西林/他唑巴坦、阿米卡星和妥布霉素也较敏感。结论重视病原学检查及耐药监测，合理使用抗菌药物。

Pathogens distribution of hospital infection and the drug resistance of inpatient

Objective To study pathogen distribution of infection and present drug-resistance conditions of the commonly encountered pathogens. Methods The statistics of the antimicrobial susceptibility testing of all the clinical isolates from July 2007 to June 2008 in our hospital was conducted. Results Totally 1189 bacteria strains were isolated. From them 372 （31.3%） were Gram-positive bacteria,817 （68.7%） were Gram- negative bacteria,23.5% of which were Escherichia coli, 12.4% were Klebsiella pneumonice and 10. 3% were Staphylococcus aureus ; Statistics of drug sensibility test suggested, Gram-positive cocci isolated from the clinical issue be highly sensitive to vancomycin, linezolid. They were still sensitive to nitrofurantoin, rifampicin, and lower sensitive to other antibiotics. Gram-negatives were high sensitive to imipenem. They were still sensitive to piperacillin/tazobactam, amikacin and tobramycin. Conclusion It should pay attention to the pathogenic detection and rational use of antimicrobial agent.