| p16和Ki-67免疫细胞化学染色在宫颈ASCUS中的应用价值 |
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| 引用本文： | 张建兰,王夷黎,禤坚艳,柳晓春,彭敏,周东华.p16和Ki-67免疫细胞化学染色在宫颈ASCUS中的应用价值[J].实用妇产科杂志,2010,26(4). |
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| 作者姓名： | 张建兰 王夷黎 禤坚艳 柳晓春 彭敏 周东华 |
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| 作者单位： | 广东省佛山市妇幼保健院,广东,佛山,528000 |
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| 基金项目： | 广东省卫生厅医学研究基金 |
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| 摘 要： | 目的:探讨液基薄层细胞学检测(TCT)剩余细胞学标本进行p16和Ki-67的免疫细胞化学染色,作为宫颈细胞学检查未明确诊断意义的不典型鳞状上皮细胞(ASCUS)中的分流管理的应用价值.方法:对2008年11月至2009年7月在佛山市妇幼保健院就诊的98例细胞学检查结果为ASCUS的患者进行p16、Ki-67免疫细胞化学染色检测,并与阴道镜下病理活检结果比较.结果:p16、Ki-67表达阳性率随着宫颈病变程度的加重而升高,与病变级别呈正相关.p16在高级别鳞状上皮病变(HSIL)组和低级别鳞状上皮病变(LSIL)组中的阳性表达率与炎症组间比较,差异有统计学意义(P<0.05).Ki-157在HSIL组中的阳性表达率与LSIL组和炎症组比较,差异有统计学意义(P<0.05).p16和Ki-67的免疫细胞化学染色检出HSIL及鳞状细胞癌(SCC)的敏感度为83.3%(20/24)和91.7%(22/24);特异度为80.4%(74/92)和86.0%(74/86).结论:利用TCT剩余细胞学标本进行p16和Ki-67的免疫细胞化学染色,是一种有效、简便的ASCUS分流管理的生物学标记物,可提高HSIL的检出率,使高危患者得到及时有效的治疗.
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| 关 键 词： | 宫颈肿瘤 未明确诊断意义的不典型鳞状上皮细胞 液基细胞学检测 |
The Clinical Value of p16 and Ki-67 Immunocytochemical Stain in Cervical Atypical Squamous Cells Undefined Significance |
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| ZHANG Jianlan,WANG Yili,XUAN Jianyan,et al.The Clinical Value of p16 and Ki-67 Immunocytochemical Stain in Cervical Atypical Squamous Cells Undefined Significance[J].Journal of Practical Obstetrics and Gynecology,2010,26(4). |
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| Authors: | ZHANG Jianlan WANG Yili XUAN Jianyan |
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| Institution: | ZHANG Jianlan,WANG Yili,XUAN Jianyan,et al(Foshan Maternal , Child Health Hospital,Foshan Guangdong 528000,China) |
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| Abstract: | Objective:To explore the relationship between p16,Ki-67 immunocytochemical stain and pathological classification in cervical atypical squamous cells undefined significance(ASCUS)in residual cell of thinprep liquid-based cytology test(TCT).Methods:98 cases who suffering from ASCUS in TCT were collected in Foshan maternal and child health hospital from Nov,2008 to Jul,2009.And then the expressions of p16 and Ki-67 in the cervical cells were evaluated by immunocytochemical stain.The result was compared with th... |
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| Keywords: | p16 Ki-67 Cervical tumor Atypical squamous cells undefined significance Liquid-based cell lamina p16 Ki-67 |
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