激素型股骨头坏死的发病机制研究

目的 探讨皮质激素引起的股骨头坏死的发生机制。方法 利用新西兰大白兔制成实验性激素性股骨头坏死的动物模型。通过血脂化验及对肝，股骨头标本病理切片的透射电镜检查，动态观察其坏死过程。结果 血脂升高与时间呈正相关，实验组骨细胞脂变，坏死，电镜下见细胞外脂质增多，继而发生细胞内脂质沉积，细胞粒浓度，碎裂，溶解等细胞坏死现象，结论皮质激素的使用能引起体内脂代谢紊乱，高脂血症及肝脂变，继之出现股骨头内骨细胞

Pathogenetic study of femoral head necrosis caused by cortical steroid

Objective To study cortical steroid caused femoral head necrosis.Methods We designed an experimental animal model of femoral head necrosis through cortical steroid administration.Lipid analyses of blood samples were made and examined specimens from livers and femoral heads were studied with HE,TEM methods.Results Cortical steroid resulted in dearrangement of fat metabolism,lipid change of liver and hyperlipemia.Conclusion The pathogenesis of femoral head necrosis is due to fatty degeneration of osteocytes.