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Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer |
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| Authors: | Binbing Ling Lifeng Chen Jane Alcorn Baohua Ma Jian Yang |
| Affiliation: | (1) Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan, S7N 5C9, Canada;(2) Entry-Exit Inspection and Quarantine Bureau, Foshan, Guangdong, 528200, People’s Republic of China; |
| Abstract: | Sphingosine-1-phosphate (S1P) is an important regulator of cancer development and progression. Its cellular concentration is controlled predominantly by sphingosine kinase (SK) and sphingosine-1-phosphate lyase (SPL). In the current study we showed that mRNA expressions for both SK and SPL were up-regulated throughout all four disease stages in human breast cancer patients. Exogenous administration of S1P produced a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhanced the cytotoxicity of anticancer drug docetaxel against MCF7 cells. |
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