地尔硫微量注射泵静脉注射法与静脉滴注法治疗高血压急症的比较

目的：观察地尔硫静脉注射治疗高血压的疗效。方法：高血压急症病人５４例，分为Ａ组２３例，采用微量注射泵静脉注射法，将注射用地尔硫２００～４００ｍｇ溶于０．９％氯化钠注射液或５％葡萄糖注射液５０ｍＬ，给药剂量按３～１０μｇ／（ｋｇ·ｍｉｎ），根据血压情况，因人而异调整剂量；Ｂ组３１例采用常规静脉滴注法，将注射用地尔硫５０ｍｇ溶于０．９％氯化钠注射液或５％葡萄糖注射液２５０ｍＬ在２～４ｈ内滴完。结果：Ａ组总有效率９６％与Ｂ组的９３％差别无显著意义（Ｐ＞０．０５）。２组治疗后１０，２０，３０，６０ｍｉｎ收缩压和舒张压与其前一观察时刻的相应血压值配对ｔ检验，差别均有非常显著意义（Ｐ＜０．０１）。２组组间相应４个时段的降压幅度差别均无显著意义（Ｐ＞０．０５）。２组不良反应均轻微。结论：注射用地尔硫治疗高血压急症见效快，安全性好，微量注射泵静脉注射给药可获持久而稳定的降压效果。

Infusion pump vs intravenous drip of diltiazem in treating hypertension emergency

AIM: To study the therapeutic effect of diltiazem injection in treating hypertension emergency. METHODS: Patients with hypertension emergency (n=54) were assigned to 2 groups. Group A of 23 patients (M 18, F 5; age 60±s 14 a; at 9±4 a of hypertension) received diltiazem 200_400 mg in 0.9% sodium chloride or 5% glucose 50 mL iv 3_10 μg/(kg·min) individually based on blood pressure] with microinfusion pump. Group B of 31 patients (M 24, F 7; age 58±10 a; at 10±6 a of hypertension) received diltiazem 50 mg in 0.9% sodium chloride or 5% glucose 250 mL iv gtt in 2_4 h. RESULTS: The remarkable effective rates of group A and group B were 57% and 61% respectively; their effective rates were 39% and 32% respectively. The total response rates in group A 96%, was similar to that of group B 93% (P>0.05). With treatment of 10 min, 20 min, 30 min and 60 min there were significant differences (P<0.01) regarding the 2 gorups' systolic and diastolic BP_reducing ranges as compared with the preceding corresponding BP value. There were no significant differences (P>0.05) in the systolic and diastolic BP_reducing ranges during the four corresponding periods of time between the 2 groups. Adverse reactions were mild in 2 groups. CONCLUSION: Diltiazem injection is an effective and safe drug in treating hypertension emergency, and intravenous injection of it with microinfusion pump has a lasting and stable therapeutic effect and is recommended for clinical application in particular.