立体定向放射治疗脑转移瘤疗效分析

目的 分析立体定向放射疗法(SRT)治疗脑转移瘤的临床疗效。方法 回顾性分析66例脑转移瘤全脑放射治疗(WBRT)追加SRT和26例脑转移瘤单纯SRT的结果,分析两者在Karnofsky评分、颅内肿瘤复发率、一年生存率等方面的状况。结果 WBRT+SRT组在颅内肿瘤复发率(13.3%和42.2%)、中位复发时间(10.5个月和4.2个月)、中位生存期(13.0个月和6.5个月)与单纯SRT组相比有显著性差异(P<0.05),但在Karnofsky评分、治疗有效率、一年生存率、死亡率的差异均无统计学意义。结论 WBRT+SRT能明显改善患者的生存质量,降低肿瘤颅内复发率,是脑转移瘤的一种理想局部治疗手段。

Analysis of stereotatic radiotherapy for brain metastases

Objective To investigate the effect of stereotatic radiotherapy (SRT) for brain metastases.Methods Retrospect compare 66 patients treated by SRT with whole brain radiotherapy(WBRT+ SRT) to 26 patients treated by SRT alone. Results The patients treated by WBRT+ SRT had significantly benefit in lesions recurrence (13.3% vs 42.2%), middle recurrence time (10.5 months vs 4.2 months) and middle survival time(13 months vs 6.5 months) over the patients treated by SRT, respectively(P<0.05). But there are no different in terms of improving of Karnofsky score, effective rate, one-year survival rate, one-year death rate between the two groups. Conclusion WBRT+ SRT play an important role in treating brain metastases, by improving patients' life quantity and reducing recurrence.