The effect of low-dose interferon treatment on visual evoked potentials |
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Authors: | Michael Moschos Emanouel Manesis Efthimios Panagakis Dimitrios Brouzas Stephanos Hadziyannis George Theodossiadis |
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Institution: | (1) University Eye Clinic of Athens, General Hospital of Athens, Athens, Greece;(2) Academic Department of Medicine, General Hospital of Athens, Athens, Greece;(3) Department of Ophthalmology, ‘Hippokration’ General Hospital of Athens, Athens, Greece;(4) 144 Kountouriotou str, 18535 Piraeus, Greece |
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Abstract: | Patients suffering from chronic viral hepatitis, treated with interferon alpha-2b in a dose of 3 million units trice weekly
subcutaneously, were studied. The influence of interferon on the optic nerve was evaluated by measuring the P100 implicit
time of the visual evoked potentials. The results before the treatment were compared with those after 6 and 12 months of therapy,
as well as with those of normal subjects. There were statisticaly significant differences between the groups. Furthermore,
in 10 of 56 eyes (17.8%) after 6 months of treatment, and 8 of 22 eyes (36.3%) after 12 months of treatment, the P100 was
abnormally delayed. The long term neurovisual effects of low-dose interferon are currently under investigation. |
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Keywords: | Hepatitis B hepatitis C interferon alpha-2b P100 implicit time visual evoked potentials |
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