| PCNA、CD_(44)V_6及MMP-2表达对膀胱移行细胞癌的预后价值 |
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| 引用本文： | 程玉峰,刘恩靖,王洪同,梁学志,米振国. PCNA、CD_(44)V_6及MMP-2表达对膀胱移行细胞癌的预后价值[J]. 实用医药杂志(山东), 2002, 19(7): 527-529 |
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| 作者姓名： | 程玉峰 刘恩靖 王洪同 梁学志 米振国 |
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| 作者单位： | [1]148医院，山东周村255300 [2]山西医科大学第一医院，山西太原030001 |
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| 摘 要： | 目的探讨PCNA,CD44V6,MMP-2在膀胱移行细胞癌中的表达对预后的价值。方法应用免疫组化方法对50例膀胱移行细胞癌、8例正常膀胱粘膜标本进行PCNA、CD44V6及MMP-2检测;对影响预后的多个指标进行Cox回归分析,筛选有预后价值的指标。结果结果在α=0.1水平建立了MMP-2表达、病理分级二因素Cox模型,h(t,x)=ho(t)exp(1.2419Grade+2.3138MMP-2),模型经似然比检验,P=0.0001。结论MMP-2表达及病理分级对膀胱移行细胞癌患者有预后价值。
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| 关 键 词： | PCNA CD44V6 MMP-2 膀胱肿瘤 预后 |
| 修稿时间： | 2002-03-18 |
The prognostic value of the expression of MMP-2 in TCCB |
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| Cheng Yufeng,Liu Enjing,Liang Xuezhi,et al.. The prognostic value of the expression of MMP-2 in TCCB[J]. Practical Journal of Medicine & Pharmacy, 2002, 19(7): 527-529 |
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| Authors: | Cheng Yufeng Liu Enjing Liang Xuezhi et al. |
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| Affiliation: | Cheng Yufeng,Liu Enjing,Liang Xuezhi,et al.No.148Hospital of PLA,Zibo255300,China |
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| Abstract: | Objective To search the expression of PCNA,CD44V6,MMP-2in transitional cell carcinoma of bladder(TCCB)and evaluate their prognostic values.Methods Paraffin-embedded sections of50bladder tumors and8normal bladder tissues were investigated by immunohistochemistry for PCNA,CD44V6and MMP-2;the indexes affecting the prognosis of TCCB were analysed using Cox regression model.Results The Cox model containing MMP-2expression and pathological grading was established on theα=0.1level,h (t,x)=ho (t)exp (1.2419Grade+2.3138MMP-2).The model was analyse d using Likelihood Ratio Test.The differences were significant(P<0.01).Conclusion The expression of MMP-2and pathological grade can offer valuable prognostic information for the patients of TCCB. |
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| Keywords: | PCNA CD44V6MMP-2Bladder carcinoma Prognosis |
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