^125I粒子植入治疗恶性肿瘤机制的研究进展

放射治疗是治疗恶性肿瘤的主要手段之一,始于19世纪末期.而放射性粒子组织间近距离放疗距今也已有近100年的历史.放射性^125I粒子植入治疗是近距离放射治疗的一种,具有低剂量率、持续照射、可反复植入等特点,与外放疗相比,其高度适形、提高肿瘤靶区剂量、降低周围正常组织受量,减少并发症,取得了非常理想的局部控制率.近年来,放射性^125I粒子在临床治疗肿瘤方面应用日渐广泛,具有高精度、微创,疗效肯定等优势,是一种理想的局部治疗方法.但人们对^125I粒子如何以低剂量率、连续照射方式杀伤癌细胞的作用机制尚不十分清楚,各种肿瘤的治疗剂量都是参照外放射治疗的剂量移植而来.^125I粒子治疗肿瘤的机理及其相关基础实验研究国内外报道的均不多,缺乏相关基础实验资料,现就这一领域的研究进展加以综述.

Recent progress in the mechanism of 125I seed implantation for cancer

Radiation therapy is the main method for cancer,which began in the late 19 century. There are nearly 100 years of brachytherapy and 125I seed implantation is one kind of it. 125I seed has low dose and irradiate continuously. It can be implantation repeatedly. Compared with external radiation therapy, it is highly conformal, much more effective with minimal damage and few complications in treating malignant tumors. In recent years, 125 I implantation for malignant tumors has been widely used in China. It is an ideal local treatment. But we still do not know its mechanism ,the dose are usually based on the external radiation therapy. Research and related basic experiments are not reported much at home and abroad. Now, we will review the recent progress in this area.