大鼠基底前脑中神经降压肽样和甘丙肽样神经元的老年变化

作者用免疫组化法及显微分光光度计研究了年轻(4—5月)及老年(2—24月)大鼠基底前脑中神经降压肽样(NT-L)和甘丙肽样(GAL-L)胞体及纤维终末的老年变化,NT-L胞体主要位于基底前脑的外侧隔核(LS),斜角带核(DBN)及腹侧苍白球(VP)中,NT-L纤维终末主要位于LS及VP中,GAL-L胞体主要位于内侧隔核(MS)及DBN中,LS和VP中仅有少量纤维终末。老年大鼠LS,DBN及VP中NT-L胞体的数量以及MS,DBM中GAL-L胞体的数量均比年轻大鼠明显减少,光吸收率明显下降,我们的结果表明大鼠基底前脑中的NT-L及GAL-L神经元有明显的老年变化,此种变化的意义有待进一步研究。

Aging changes of neurotensin -like and galanin -like neurons in rat basal forebrain

Aging changes of neurotensin - like (NT - L ) and galanin - like (GAL -L) cell bodies and fiber terminals in the basal forebrain from young (4-5 months )to old (22-24 months )rats were studied by immunohistochemistry and microspectrometric technique . NT- L cell bodies were mainly located in lateral scptal nucleus ( LS ), nucleus of diagonal band (DBN ), and ventral pallidum (VP). NT-L fiber terminals were seen mainly in LS and VP . GAL -L cdl bodies were observed mainly in medial septal nucleus (MS ) and DBN , a few GAL- L fiber terminals were found in LS and VP . A marked decrease in number of NT - L cell bodies in LS , DBN , VP , and GAL- L cell bodies in MS, DBN was found in old rats as compared with young animals , the light absorbance was also reduced remarkably These results show that there are marked aging changes of NT-L and GAL - L neurons in rat basal forebrain . The meaning of these changes remains to be further studied .