Clinicopathological features of hereditary breast cancer |
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Authors: | Tadashi Nomizu Atsuo Tsuchiya Masahiko Kanno Naoto Katagata Fumiaki Watanabe Yoshio Yamaki Rikiya Abe Yoshio Miki |
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Institution: | (1) Department of Surgery, Hoshi General Hospital, 2-1-16 Omachi, 963 Koriyama, Japan;(2) Second Department of Surgery, Fukushima Medical College, Japan;(3) Department of Human Genome Analysis, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan |
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Abstract: | The possible role of germline mutations ofBRCA1 andBRCA2 as causative agents of familial breast cancer was assessed. Their possible involvement in the carcinogenesis of hereditary
breast cancer was investigated using 63 clinically suspect families. Twenty-one lineages (33.3%) had mutations in one of the
twoBRCA genes. This relatively low incidence suggested that germline mutations in unknown genes are involved in the carcinogenesis
of hereditary breast cancer in the Japanese population. However, the clinicopathological features characteristic of hereditary
breast cancer, such as early disease onset, a high incidence of bilateral breast cancer, and a high incidence of multiple
primary carcinomas in other organs were confirmed in the present study. |
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Keywords: | Hereditary breast cancer Familial breast cancer BRCA genes Germline mutation |
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