新生儿溶血病D-二聚体变化的临床研究

目的探讨新生儿溶血病D-二聚体水平变化及临床意义。方法选取新生儿溶血病患儿60例，按照胆红素水平分为非重度组（34例）和重度组（26例）。同期出生的40例正常足月儿为对照组。检测各组D-二聚体及纤维蛋白原(FIB)水平的变化。结果重度组、非重度组D-二聚体水平分别为(9.29±11.34)、(0.84±0.77) mg/L]明显高于对照组(0.45±0.06) mg/L](P＜ 0.01或＜0.05)，重度组明显高于非重度组(P＜0.01)。各组FIB水平比较差异无统计学意义(P＞0.05)。结论重度新生儿溶血病患儿体内存在高凝状态，血浆D-二聚体水平测定对新生儿溶血病患儿的病情判断和治疗有一定的价值。

Clinical research on the D-dimer changes in haemolytic disease of newborn

Objective To investigate the change of D-dimer in haemolytic disease of newborn and its clinical significance. Methods Sixty cases with haemolytic disease of newborn were divided into nonserious group(34 cases) and serious group(26 cases) by the level of bilirubin, 40 cases of normal neonatus (control group) were also selected. The levels of D-dimer and fibrinogen(FIB) were measured and compared.Results The level of D-dimer in serious group and non-serious group (9.29 ± 11.34), (0.84 ± 0.77 ) mg/L]was higher than that in control group (0.45 ± 0.06) mg/L](P ＜ 0.01 or ＜ 0.05 ),the level of D-dimer in serious group was higher than that in non-serious group (P＜ 0.01 ). There was no significant difference in the level of FIB among the three groups (P ＞ 0.05). Conclusions There is hypercoagulability in the serious haemolytic disease of newborn. It is valuable to detect plasma D-dimer density for serious haemolytic disease of judgement and treatment.