鼻内窥镜手术联合丝裂霉素治疗 腔鼻窦内翻性乳头状瘤

目的 探讨鼻内窥镜手术联合丝裂霉素治疗鼻腔鼻窦内翻性乳头状瘤(NIP)的临床效果。方法 将75例NIP患者按随机数字表法分成治疗组（鼻内窥镜手术联合丝裂霉素治疗）38例和对照组（单纯鼻内窥镜手术治疗）37例。结果 治疗组均未见并发症，术后症状消失。随访恢复良好，术腔上皮化，1例Ⅲ级患者术后3个月复发，再次术后随访5年，未复发。对照组1年内复发3例，在第2年复发4例，5例经再次手术痊愈，2例恶变。治疗组与对照组疗效比较差异有统计学意义(X2=9.86，P＜ 0.05)。结论 鼻内窥镜手术联合丝裂霉素治疗NIP，术中、术后给予丝裂霉素局部辅助治疗，能有效抑制NIP复发与癌变，提高治愈率。

Endoscopic sinus surgery combined with mitomycin in nasal inverted papillom

Objective To explore the effect of endoscopic sinus surgery combined with mitomycin in nasal inverted papilloma (NIP). Method The clinical data of 75 patients with NIP was retrospectively analyzed and divided into treatment group (endoscopic sinus surgery combined with mitomycin treatment, 38 cases) and control group (endoscopic sinus surgery treatment, 37 cases) by random digits table. Results There was no complication in treatment group, the symptoms disappeared after treatment, good recovery and surgery epithelization was found after follow-up, 1 case of grade Ⅲ recurred at 3 months after treatment and followed up for 5 years without recurrence. In control group, 37 cases of conventional dressing endoscopic treatment, recurrence within 1 year in 3 cases, 4 cases of recurrence in the second year, 5 cases of reoperation cured, 2 cases of malignant transformation. The efficacy was no statistically significant between two groups ( X2 =9.86,P ＜ 0.05). Conclusion Endoscopic sinus surgery combined with mitomycin in treatment of NIP, intraoperative and postoperative adjuvant therapy given to the local mitomycin, inhibit their growth and development, can inhibit the NIP recurrence and improve the cure rate.