Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression. |
| |
| Authors: | Inmaculada Bellido Zaida Díaz-Cabiale Patricia A Jiménez-Vasquez Beth Andbjer Aleksander A Mathé Kjell Fuxe |
| |
| Institution: | Department of Pharmacology and Clinical Therapeutics, School of Medicine, University of Malaga, Malaga, Spain. ibellido@uma.es |
| |
| Abstract: | The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of (125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with respect to the Flinders Resistant Line rats (38+/-3.6 fmol/mg protein) (42%, P<0.05) without changes in galanin receptor affinity and with a significant reduction (32.3%, P<0.05) of galanin-like immunoreactivity in the dorsal raphe. The results indicate that enhancement of galanin receptor function in the dorsal raphe rich in 5-HT neurons could be a mechanism involved in the production of depressive-like activity in this animal model of depression. |
| |
| Keywords: | |
|
|
