2018年成都地区淋病奈瑟菌对抗生素耐药性的结果分析

目的 了解2018年成都地区淋病奈瑟菌对5种抗生素的耐药性及产β-内酰胺酶淋病奈瑟菌(PPNG)和质粒介导的高度耐四环素淋病奈瑟菌(TRNG)的流行状况。方法 用琼脂稀释法测定5种抗生素的最小抑菌浓度(MIC)和用纸片酸度法检测β-内酰胺酶。结果 112株淋病奈瑟菌检测出PPNG 58株(51.79%)、TRNG 31株(27.68%)，青霉素和阿奇霉素的耐药率分别为76.79%和25.00%，检测出淋病奈瑟菌对环丙沙星全部耐药，同时发现一株耐大观霉素的菌株，未发现有对头孢曲松耐药的菌株。淋病奈瑟菌多重耐药41株(36.61%)，其中对环丙沙星、青霉素和四环素同时耐药24株比例(21.43%)最高，对环丙沙星、青霉素、四环素、阿奇霉素和大观霉素同时耐药1株比例(0.89%)最低。结论

Analysis of antibiotic resistanc of Nersseria gonorrhoeae isolates from Chengdu in 2018

Objective To investigate the antibiotic resistance of Neisseria gonorrhoeae (NG) to five antibiotics and the prevalence of penicillinase-producing NG (PPNG) and tetracycline-resistant NG (TRNG) in Chengdu. Methods Minimum inhibitory concentrations (MIC) of five antibiotics were determined using the agar dilution method, and β-lactamase was analyzed by the paper acidimetric method. Results A total of 112 NG isolates were examined. There were 58 PPNG (51.79%) and 31 TRNG (27.68%) demonstrated respectively. The resistant rates to penicillin and azithromycin were 76.79% and 25.00% respectively. All strains were found to be resistant to ciprofloxacin. One spectinomycin resistant strain was detected. No ceftriaxone resistant strains were found. Multidrug resistant rate was 36.61%(41/112). The resistant rate of 24 strains were high to ciprofloxacin, penicillin, and tetracycline at the same time, while the resistant rate of one strain was low to ciprofloxacin, penicillin, tetracycline, azithromycin, and spectinomycin at the same time. Conclusion It is important to strengthen the NG surveillance of antimicrobial resistance, and ceftriaxone and spectinomycin are the first-choice drug for treatment of NG in