Abstract: | Objective The distribution and drug resistance of clinical isolated pathogens were analyzed to provide reference for rational use of antimicrobial agents. Methods By the method of retrospective analysis, the pathogenic bacteria isolated from the Laboratory Department of Weifang Medical college from January 2016 to August 2018 were analyzed and their clinical distribution and drug resistance were analyzed. Results The results of comprehensive analysis of 8,941 non-repetitive bacteria showed that 5,176 strains (57.89%) were Gram-negative bacteria, 2,587 strains (28.93%) were Gram-positive bacteria and 1,178 strains (13.18%) were fungi. Gram-negative bacteria mainly were Escherichia coli (20.88%), Klebsiella pneumoniae (10.09%), and Pseudomonas aeruginosa (7.66%). Gram-positive bacteria mainly were Staphylococcus aureus (7.52%) and Staphylococcus epidermidis (5.30%). The main fungi were Candida albicans (12.33%). The most sample types were sputum (27.50%), followed by urine and blood. In pediatrics, gastroenteroanal disease surgery, urology, the detection rate of pathogens was in the first three departments. Escherichia coli and Klebsiella pneumoniae had higher resistance to ampicillin-sulbactam, cefazolin and SMZ-TMP, but were sensitive to piperacillin-tazobactam. Pseudomonas aeruginosa and Acinetobacter baumannii had higher resistance to cefotetan and erythromycin, and they were sensitive to amikacin. Among Staphylococcus aureus, a total of 195 strains of MRSA accounted for 29.02%. Staphylococcus aureus and Staphylococcus epidermidis were more resistant to penicillin G and erythromycin, but sensitive to vancomycin, teicoplanin, and linezolid. Conclusion The problem of drug resistance of clinical isolated pathogens was serious. The hospital should strengthen the dynamic monitoring of drug resistant bacteria and carry out individualized drug use according to the results of drug resistance in order to reduce the occurrence of drug resistance and improve the accuracy of treatment. |