肠道微生物菌群在肿瘤不同疗法中的研究进展#br#

肠道微生物菌群由共生细菌和生活在宿主肠道上皮的其他微生物组成，影响多种生理功能，如维持肠道上皮内稳态及调节新陈代谢、炎症和免疫力等。肠道微生物菌群也参与肿瘤的发生发展和转移。肠道微生物菌群能够影响机体对肿瘤治疗的效果及毒副作用的敏感性。在肿瘤治疗中，肠道微生物菌群与手术、化疗、放疗和免疫治疗等有着密切关系，有可能成为精准医疗和个性化医疗的前沿方向之一。本文就肠道微生物菌群在肿瘤不同疗法中的研究进展作一简要综述。

Research advances of intestinal microflora in the application of different cancer therapies

The intestinal microflora is composed of symbiotic bacteria and other microorganisms living in the intestinal epithelium of the host. They influence a lot of physiological functions， including homeostasis maintenance of intestinal epithelial barrier and regulations of metabolism， inflammation and immunity. Moreover， intestinal microflora is also involved in the cancer occurrence， progression and metastasis. Intestinal microflora can affect the bodys response to cancer therapies and sensitivity to side effects. In the treatment of cancer， intestinal microflora is closely related to surgery， chemotherapy， radiotherapy and immunotherapy， and it may become one of the frontiers of precise medical treatment and personalized medical treatment. This article reviews the progress of intestinal microflora in cancer therapy.