老年肺癌化疗患者营养状态及与癌因性疲乏的相关性

目的探讨老年非小细胞肺癌患者化疗期间营养状态变化特点及与癌因性疲乏的相关性,为制定缓解癌因性疲乏干预措施提供参考。方法选取115例老年非小细胞肺癌化疗患者,在化疗第1个周期前1d(T0)及第7天(T1)、第2个周期前1d(T2)及第7天(T3)、第4个周期结束后第7天(T4)采用营养风险评估表(NRS-2002)进行营养状态评估,在T4同时采用癌因性疲乏量表(CRF)评估。结果在T0、T1、T2、T3、T4NRS-2002评分分别为(3.05±1.19)、(3.80±1.24)、(2.85±1.22)、(3.19±1.21)、(3.06±1.09)分,各时间点评分比较,差异有统计学意义(P<0.01);营养不良发生率分别为10.4%、27.8%、8.7%、18.3%、14.8%。T4时间点CRF总分及躯体疲乏、情感疲乏、认知疲乏维度评分分别为(40.60±6.48)、(14.58±3.87)、(14.28±1.17)、(11.74±2.84)分。各时间点NRS-2002评分与T4时间点躯体疲乏、认知疲乏及CRF总分呈正相关性(均P<0.05)。结论老年非小细胞肺癌患者化疗期间营养不良及营养风险比例较高,其变化趋势呈现“波浪”形;营养状态与CRF发生有关,需积极开展营养支持,以降低CRF程度。

Nutritional status and its relationship with cancer-related fatigue among elderly lung cancer patients undergoing chemotherapy

Objective To explore the changing characteristics of nutritional status and its correlation with Cancer-related Fatigue(CRF)among elderly Non-small Cell Lung Cancer(NSCLC)patients undergoing chemotherapy,so as to provide reference for developing targeted intervention to alleviate CRF.Methods Totally 115 elderly NSCLC patients undergoing chemotherapy were selected,who were then investigated using Nutritional Risk Screening 2002(NRS-2002)at one day before(T0)and the 7th day of the first cycle of chemotherapy(T1),one day before(T2)and the 7th day of the second cycle of chemotherapy(T3),and the 7th day after the fourth cycle of chemotherapy(T4),and the patients were also investigated utilizing CRF scale at T4.Results The score of NRS-2002 was(3.05±1.19),(3.80±1.24),(2.85±1.22),(3.19±1.21)and(3.06±1.09)at T0,T1,T2,T3 and T4 respectively,and there was significant difference among the scores(P<0.01).The incidence of malnutrition was 10.4%,27.8%,8.7%,18.3%and 14.8%at each time point.The total CRF score and the score of physical fatigue,emotional fatigue,cognitive fatigue was(40.60±6.48),(14.58±3.87),(14.28±1.17)and(11.74±2.84)at T4.The NRS-2002 score at each time point were positively and significantly correlated with the score of physical fatigue,cognitive fatigue and the total CFS score at T4(P<0.01 for all).Conclusion The proportion of malnutrition and nutritional risk among elderly NSCLC patients during chemotherapy are high,and its trend of change appears as a"wave".In addition,nutritional status has something to do with CRF,so it is necessary to conduct active nutritional support to reduce the degree of CRF.