我国造血干细胞移植现状——中国骨髓移植登记处1998年登记结果分析

目的 探讨造血干细胞移植（ＳＣＴ）的应用及改善预后的措施。方法 总结１９９８年８月底中国骨髓移植登记处（ＣＢＭＴＲ）收到的全国登记的ＳＣＴ病例资料，统计患者长期生存率和复发率。结果 迄今国内有６８个单位已开展ＳＣＴ，其中３０个单位已开展异基因ＳＣＴ。

Current status of hematopoietic stem cell transplantation in China:an analysis of results registered at China Bone Marrow Transplantation Registry in 1998

Objective To explore the application of stem cell transplantation(SCT) and the strategy for improving the SCT outcome. Methods Summarizing the data registered at China Bone Marrow Transplantation Registry(CBMTR) in 1998 to estimate the probabilities of disease free survival(DFS). Results There were 68 SCT teams registered.Thirty of them performed both allogeneic SCT(allo SCT) and autologous SCT(ASCT).Up to Aug 31,1998,a total of 1?840 SCT cases were registered, 38.6% of them were allo SCT, 59.0% were ASCT,and 9 cases were syngeneic SCT.The probabilities of 3 year DFS for acute myeloid leukemia(AML) and acute lymphoid leukemia(ALL) in first complete remission(CR 1) were 70.0% and 48.2%, respectively.For chronic myeloid leukemia(CML) in first chronic phase(CP 1), 3 year DFS was 64.2%.The probability of 3 year DFS of ASCT for the AML CR 1 patients was similar to that of the AML >CR 1 patients, but after ASCT,the ALL >CR 1 patients had much less probability of 3 year DFS than that of the CR 1 patients.There were 5 cases of volunteer marrow transplantation(VMT) registered.Two of them are alive,two died of relapse,and one died of infection. Conclusion SCT including VMT should be performed while patients were in an ideal state of remission.