| 16例妇科肿瘤中P16基因缺失的研究 |
| |
| 引用本文： | 赵春艳,张耀铮,孙静. 16例妇科肿瘤中P16基因缺失的研究[J]. 大连医科大学学报, 2000, 22(1): 41-43 |
| |
| 作者姓名： | 赵春艳 张耀铮 孙静 |
| |
| 作者单位： | 1. 大连医科大学检验系,116027
2. 大连医科大学检验系94级 |
| |
| 摘 要： | 目的；研究Ｐ１６基因缺失与妇科肿瘤发生与恶性变的关系：方法：采用聚合酶链式反应技术（ＰＣＲ），扩增１６例妇科肿瘤组织中的Ｐ１６基因。结果：１６例妇科肿组织中，有１２例为恶性肿瘤。其中有４例出现Ｐ１６基因缺失，缺失率为３３．３％；有４例为良性肿瘤。未见Ｐ１６基因缺失，结论：Ｐ１６基因缺失可能与妇科肿瘤的发生及恶性变有关。
|
| 关 键 词： | 妇科瘤 P16基因 基因缺失 聚合酶链反应 |
| 文章编号： | 1000-5676(2000)01-0041-03 |
| 修稿时间： | 1999-07-13 |
Deletion of P16 gene in 16 gynaecological tmnors |
| |
| Zhao Chunyan,Zhang Yaozheng and Sun Jin. Deletion of P16 gene in 16 gynaecological tmnors[J]. Journal of Dalian Medical University, 2000, 22(1): 41-43 |
| |
| Authors: | Zhao Chunyan Zhang Yaozheng Sun Jin |
| |
| Affiliation: | Zhao Chunyan,Zhang Yaozheng,Sun Jin(Department of Laboratory , Dalian Medical University, Dalian , China) |
| |
| Abstract: | Objective:To investigate the possible relationship between deletion of P16 gene and abiogenesis of gynaecological tumor.Methods:16 gynaecologial tumor tissue were amplified for P16 gene by polymerase chain reaction-based analysis.Result:Of 12 gynaecological specimens,4(33.3%)showed homozygous deletion of P16 gene.No deletion was detected in 4 malignant tumor.Conclusions:Deletion of P16 gene might contribute to the abiogenesis and aggraration of gynaecological tumor. [WT5HZ] |
| |
| Keywords: | gynaecological tumor P16 gene gene deletion polymerase chain reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《大连医科大学学报》浏览原始摘要信息 |
|
点击此处可从《大连医科大学学报》下载免费的PDF全文 |
