全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病的临床研究

目的 研究全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病可产生的协同作用. 方法 我们对我院2006～2008年共9例急性早幼粒细胞性白血病采用两药联合化疗,予ATRA 10mg口服3-4次/天、As2O310mg静脉滴注3-4h每天1次,于第3天加用蒽环类抗肿瘤抗生素药物+阿糖胞苷化疗. 结果 联合治疗患者6例初发全部一疗程达到完全缓解(cR),复发病例中2例CR,中位时间30.12±4.89天. 结论 联合应用ATRA+As2O3和蒽环类抗肿瘤抗生素药物的化疗取代以往的单药治疗,取得较好的疗效,达到完全缓解的时间缩短,血小板计数恢复快,无病生存期延长.

Clinical Study of Acute Promyelocytic Leukemia Treated by the Combination of All-trans Retinoic Acid with Arsenic Trioxide

AbstractObjectiveTo observe the therapeutic efficacy of all-trans retinoic acid(ATRA) combined with arsenic trioxide(As2O3) on acute promyelocytic leukemia(APL). Methods9 patients of APL underwent ATRA with As2O3 therapy.The patients in combination group were treated with ATRA 25mg/(m2·d) and As2O3 10mg intravenously for 3 to 4 hours per day until complete remission(CR) or for 50 days.According to the white blood cell(WBC) counts, anthracycline and cytosine arabinoside(Ara-C) were added on third day. Results6 newly-diagnosed and 2 relapse patients of the combination group were CR after first treat.The medium time to CR was 30.12±4.89 days. ConclusionATRA + As2O3 with anthracycline regiment is superior to either regiment given alone to patients with APL. It is an efficient therapeutic approach to APL patients using a combination of ATRA with As2O3.