磁共振扩散加权成像与肝硬化肝功能的相关性研究

目的：通过磁共振扩散加权成像与肝功能终末期肝病模型MELD（Model for End-Stage Liver Disease,MELD）评分的相关性研究,探讨磁共振扩散加权成像评价肝硬化病人肝功能的应用价值。方法：对30例正常志愿者及30例肝硬化病人行肝脏磁共振扩散加权成像,测量并比较正常组与病例组肝实质表观扩散系数值（ADC）,分析ADC值与MELD评分的相关性。结果：病例组ADC值较正常组降低（P〈0.01）,扩散敏感系数b=800 s/mm2时,ADC值与MELD评分有高度负相关（r=-0.69,P〈0.01）。结论：肝实质ADC值测量,对肝硬化病人肝功能的评估有较高的临床应用价值。

CORRELATION STUDY BETWEEN DIFFUSION WEIGHTED MAGNETIC REASONANCE IMAGING (MR-DWI) AND LIVER FUNCTION OF LIVER CIRRHOSIS

Objective：Through the study of correlation between magnetic resonance diffusion weighted imaging（MR-DWI） and model for end-stage liver disease to investigate the value of MR-DWI in estimating liver function of liver cirrhosis.Methods：Thirty cases of normal volunteers and 30 cases of liver cirrhosis patients were examined using magnetic resonance imaging.The apparence diffusion coefficient values（ADCS） was measured and compared between the control and experimental groups.The correlation between ADCS and MELD scores was also analyzed.Results：ADCS in experimental group was lower than that in control group（P〈0.01）.When b=800,there was significant negative correlation between patient＇s ADCS and MELD scores（r=-0.69,P〈0.01）.Conclusion：Measuring ADC value of liver had highly clinical application value for evaluating liver function in liver cirrhosis patients.