| 低分子肝素钠自微乳缓释胶囊的制备及其药效学的初步研究 |
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| 引用本文： | 胡晶晶,张钧寿,周建平. 低分子肝素钠自微乳缓释胶囊的制备及其药效学的初步研究[J]. 药学与临床研究, 2009, 17(2): 93-95 |
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| 作者姓名： | 胡晶晶 张钧寿 周建平 |
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| 作者单位： | 中国药科大学药剂教研室,南京,210009 |
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| 摘 要： | 目的:制备低分子肝素钠自微乳缓释胶囊,并初步考察该制剂体外释放特征及抗凝血效果.方法:采用天青A法测定缓释胶囊体外释放度,用毛细玻管法测定其凝血时间.结果:该缓释胶囊能达到12 h的缓释效果,其体外释放呈Higuchi方程,r=0.9975,凝血时间延长百分率最大可达到(297±21)%.结论:自微乳缓释胶囊能显著延长抗凝血时间.
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| 关 键 词： | 低分子肝素钠 凝血时间 缓释 |
| 收稿时间： | 2008-12-02 |
Preparation and pharmacodynamics of LMWH-Na loaded self-microemulsion sustained release capsule |
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| HU Jing-jing,ZHANG Jun-shou and ZHOU Jian-ping. Preparation and pharmacodynamics of LMWH-Na loaded self-microemulsion sustained release capsule[J]. Pharmacertical and Clinical Research, 2009, 17(2): 93-95 |
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| Authors: | HU Jing-jing ZHANG Jun-shou ZHOU Jian-ping |
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| Affiliation: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing 21009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 21009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 21009, China |
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| Abstract: | |
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| Keywords: | Low molecular wieght heparin-Na Coagulation time Sustained release |
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