Feline penile erection induced by transurethral administration of sodium nitroprusside |
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Authors: | Trinity J Bivalacqua Hunter C Champion Run Wang Philip J Kadowitz Paul C Doherty Wayne JG Hellstrom |
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Institution: | (1) Department of Urology SL-42, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA, US;(2) Department of Pharmacology, Tulane University Medical School, New Orleans, LA 70112, USA, US;(3) Section of Urology, Medical College of Georgia, Augusta, GA 30912, USA, US;(4) LA and VIVUS, Inc., Mountain View, California, USA, US |
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Abstract: | Nitric oxide (NO) is an important mediator in the relaxation of cavernosal smooth muscle. The aim of this study was to investigate
the in vivo feline erectile response after transurethral administration of sodium nitroprusside (SNP), a NO donor drug. Erectile
responses after administration of transurethral SNP were compared with those elicited by an intracavernosal control triple-drug
combination (1.65 mg papaverine, 25 μg phentolamine, and 0.5 μg prostaglandin E1). SNP was administered via a 20-gauge Jelco intravenous catheter in a volume of 200 μl and changes in intracavernosal pressure,
penile length, and systemic blood pressure were monitored. The control triple-drug combination was administered via a 30-gauge
needle at the end of each experiment to serve as a control reference. Transurethral administration of SNP (1–4 mg) induced
penile erection in a dose-dependent manner with minimal changes in systemic blood pressure. The maximum increase in intracavernosal
pressure and penile length after transurethral administration of SNP (4 mg) was significantly less than after the intracavernosal
injection of the control triple-drug combination (P < 0.01). These data suggest that transurethral administration of SNP can induce an erectile response in cats with minimal
side effects.
Received: 17 December 1998 / Accepted: 14 April 1999 |
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Keywords: | Penile erection Transurethral SNP Nitric oxide cGMP Erectile dysfunction |
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