| DAZL基因对人类生殖细胞分化和性腺发育影响的研究进展 |
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| 引用本文： | 赵敏英,赵涛,彭弋峰. DAZL基因对人类生殖细胞分化和性腺发育影响的研究进展[J]. 生殖医学杂志, 2010, 19(1): 71-74. DOI: 10.3969/j.issn.1004-3845.2010.01.018 |
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| 作者姓名： | 赵敏英 赵涛 彭弋峰 |
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| 作者单位： | 皖南医学院弋矶山医院,生殖医学研究所,安徽芜湖,241001 |
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| 基金项目： | 男性生精障碍的分子机制研究(子课题)G1999055905 |
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| 摘 要： | DAZL（deleted in azoospermia—like）基因是DAZ（deleted in azoospermia）基因家族的成员之一，位于常染色体上3q24，与DAZ基因高度同源。研究表明DAZL基因在人类睾丸和卵巢均有表达，在生殖细胞分化和性腺发育形成过程中扮演重要的角色。本文阐述了DAZL基因的缺失、多态性、突变及甲基化改变在人类生殖中的影响，并对其在辅助生殖技术中的价值作简要的讨论。
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| 关 键 词： | 细胞分化 人类生殖 L基因 性腺 无精子症 常染色体 基因甲基化 基因家族 |
Research progress in the effect of DAZL gene on human reproductive cell differentiation and gonadogenesis |
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| ZHAO Min-ying,ZHAO Tao,PENG Yi-feng. Research progress in the effect of DAZL gene on human reproductive cell differentiation and gonadogenesis[J]. Journal of Reproductive Medicine, 2010, 19(1): 71-74. DOI: 10.3969/j.issn.1004-3845.2010.01.018 |
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| Authors: | ZHAO Min-ying ZHAO Tao PENG Yi-feng |
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| Affiliation: | ( Reproductive medical Institute, Yijishan Hospital, Wannan Medical College, Wuhu 241001) |
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| Abstract: | DAZL（deleted in azoospermia-like） gene, an autosomal gene（chromosome 3p24）, is a member of the DAZ（deleted in azoospermia） gene family and shares a high degree of homology with the DAZ. Germ cells are the main site of DAZL family protein expression. DAZL plays an important role in the cell differentiation and gonadogenesis. In this review, the effects of the changes in deletion, polymorphism, mutation and methylation of DAZL gene on the human reproduction are introduced. And there is a brief discussion about the value of DAZL in assisted reproductive technology. |
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| Keywords: | DAZL gene Human reproduction Assisted reproductive technology |
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