可吸收椎体内支撑器的研制及植入途径研究

目的：研制用于胸腰椎骨折椎体重建的可吸收椎体内支撑器,并探讨经椎弓根植入的可行性。方法：选择100例健康成年志愿者,CT扫描其T11~L4椎骨,模拟重建T11~L4椎骨的二维、三维图像,测量椎体矢状径、横径和椎弓根内径高度、宽度。据此确定可植入支撑器的规格,并以聚-DL-乳酸（分子量40~80万）、磷酸三钙或羟基磷灰石为原料制成成品试件。将成品试件经椎弓根植入3具成人尸体标本的L1、L2椎体中,完成后摄腰椎标本正侧位X线片,并行L1、L2椎骨CT扫描、矢状面二维重建。结果：T11~L4椎体横径（32.44±2.82）~（42.13±4.10）mm,椎体矢状径（25.55±2.54）~（28.97±2.24）mm;T11~L4椎弓根内径高度（9.16±1.40）~（12.46±1.67）mm,椎弓根内径宽度（5.78±0.89）~（8.88±1.51）mm,椎弓根内径高度及宽度两侧相比,差异无统计学意义（T11~L4椎弓根内径高度：t=1.857,P=0.334;t=1.673,P=0.707;t=2.355,P=0.685;t=1.983,P=0.126;t=2.435,P=0.148;t=2.871,P=0.774。T11~L4椎弓根内径宽度：t=0.134,P=0937;t=1.962,P=0.125;t=0.453,P=0.634;t=1.983,P=0.509;t=1.643,P=0.086;t=0.851,P=0.150）。②设计的系列可吸收椎体内支撑器规格为：长20.0~27.0 mm,宽7.0~10.0 mm,高9.0~12.0 mm。③经X线及CT检查,经椎弓根植入3具成人尸体标本L1、L2椎体中的可吸收椎体内支撑器位置良好。结论：可吸收椎体内支撑器经椎弓根或经椎弓根及其外侧壁植入重建胸腰椎前中柱是可行的。

Development of centrum-vertebra-fracture-repairing absorbable supporting plugger and the study of its implantation pathway

Objective:To develop the centrum-vertebra-fracture-repairing absorbable supporting plugger(CASP)used for the vertebral reconstruction after the thoracolumbar fractures,and to explore the feasibility of CASP's implantation via the pedicle of vertebral arch.Methods:One hundred healthy adult volunteers were chosen to reconstruct the 2D and 3D images of T11-L4 vertebras through CT scanning their T11-L4 vertebras,then the vertebral sagittal diameters,the vertebral transverse diameters,heights and widths of pedic...