| 重度血瘀证与血浆遗传性假血友病因子水平及CYP2C19*2基因多态性的关系 |
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| 引用本文： | 张娅,陈慧,李灿东,吴红霞,林云钗. 重度血瘀证与血浆遗传性假血友病因子水平及CYP2C19*2基因多态性的关系[J]. 中医杂志, 2011, 52(11): 941-944,951 |
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| 作者姓名： | 张娅 陈慧 李灿东 吴红霞 林云钗 |
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| 作者单位： | 1. 福建中医药大学中西医结合研究院、中医证研究基地,福州市闽侯上街华佗路1号,350108
2. 福建医科大学省立临床医学院心内科 |
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| 基金项目： | 卫生部科学研究基金-福建省卫生教育联合攻关计划项目 |
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| 摘 要： | 目的探讨经皮冠状动脉介入术(PCI)后重度血瘀证与血浆遗传性假血友病因子(vWF)水平及CYP2C19*2基因多态性的相关性。方法将371例PCI成功的冠心病患者根据术后1周血瘀证评分标准分为非血瘀组(77例)、轻度血瘀组(193例)和重度血瘀组(101例)3组,采用PCR-RFLP基因分析方法检测CYP2C19*2基因多态性,同时采血检测血小板计数(PLT)、最大血小板聚集率(MPA)、vWF和纤维蛋白原(Fg)。结果重度血瘀组CYP2C19*2基因突变型(GA+AA)明显高于轻度血瘀组和非血瘀组(χ2=27.093,P<0.001)。多因素Logistic回归分析显示,以非血瘀组为参照系,CYP2C19*2基因突变型(GA+AA)患重度血瘀证的相对危险度(OR)为3.371(95%CI:1.557~7.295,P=0.002)。重度血瘀组MPA及vWF高于轻度血瘀组,差异有统计学意义(P<0.05)。血浆vWF的ROC曲线分析指出,vWF≥118.10%(敏感性为0.842,特异性为0.767,辨证准确率为78.6%,Youden指数0.609),中医辨证为重度血瘀证的可能性较大。结论 PCI术后CYP2C19*2基因突变患者可能易患重度血瘀证,血浆vWF测定可作为其重要的微观辨证指标。
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| 关 键 词： | 经皮冠状动脉介入术 冠心病 血瘀证 遗传性假血友病因子 CYP2C19*2 基因多态性 |
Correlation of Severe Blood-stasis Syndrome, Plasma Von Willebrand Factor and Polymorphism of CYP2C19 * 2 Gene |
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| ZHANG Ya,CHEN Hui,LI Candong,WU Hongxia,LIN Yunchai. Correlation of Severe Blood-stasis Syndrome, Plasma Von Willebrand Factor and Polymorphism of CYP2C19 * 2 Gene[J]. Journal of Traditional Chinese Medicine, 2011, 52(11): 941-944,951 |
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| Authors: | ZHANG Ya CHEN Hui LI Candong WU Hongxia LIN Yunchai |
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| Affiliation: | ZHANG Ya1,CHEN Hui2,LI Candong1,WU Hongxia2,LIN Yunchai2(1.Institute of Integrated Traditional and Western Medicine,Fujian University of Chinese Medicine,Fuzhou 350108,2.Provincial Clinical College,Fujian Medical University) |
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| Abstract: | Objective To approach the correlation among severe blood-stasis syndrome,plasma von Willebrand factor(vWF) and polymorphism of CYP2C19*2 gene in the patients after percutaneous coronary intervention(PCI).Methods Totally 371 coronary heart disease patients after receiving successful PCI were adopted in this study.One week after operation,they were divided into three groups according to the scoring criteria of blood-stasis syndrome,i.e.non blood-stasis group(77 cases),mild blood-stasis group(193 cases),and se... |
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| Keywords: | percutaneous coronary intervention(PCI) coronary heart disease blood-stasis syndrome von Willebrand factor(vWF) CYP2C19*2 gene polymorphism |
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