| 补肾活血针刺法对阿尔茨海默病模型小鼠海马脑红蛋白表达的影响 |
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| 引用本文： | 朱宏,董克礼,吴岳,李广诚,肖岚,张婷,王慧玲. 补肾活血针刺法对阿尔茨海默病模型小鼠海马脑红蛋白表达的影响[J]. 中医杂志, 2011, 52(11): 955-957 |
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| 作者姓名： | 朱宏 董克礼 吴岳 李广诚 肖岚 张婷 王慧玲 |
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| 作者单位： | 1. 中南大学湘雅三医院中医科,湖南省长沙市桐梓坡路118号,410013
2. 长沙市精神病医院 |
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| 基金项目： | 湖南省中医药管理局科研基金 |
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| 摘 要： | 目的探讨补肾活血针刺法对阿尔茨海默病模型快速老化小鼠P8(SAMP8)学习记忆能力的影响及作用机制。方法将20只5月龄雄性SAMP8小鼠随机分为针刺治疗组、模型对照组各10只,另设5月龄雄性抗快速老化小鼠(SAMR1)10只作为正常对照组。针刺治疗组予以补肾活血针刺法干预,选穴百会、血海、肾俞、膈俞,采用捻转补泻手法。模型对照组及正常对照组未予特殊处理。干预4周后,取各组小鼠海马组织,采用免疫组化法检测脑红蛋白(Ngb)的表达情况。结果模型对照组小鼠海马组织Ngb的表达水平较正常对照组减弱(P<0.01);与模型对照组相比,针刺治疗组小鼠海马组织Ngb的表达水平明显升高(P<0.01)。结论补肾活血针刺干预能够明显增强SAMP8小鼠海马组织Ngb的表达,这可能是其改善SAMP8小鼠学习记忆能力的潜在分子机制之一。
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| 关 键 词： | 针刺 阿尔茨海默病 快速老化小鼠 脑红蛋白 补肾活血 |
Effect of Acupuncture for Reinforcing Kidney and Activating Blood on the Neuroglobin Expression in Hippocampus Tissue of Alzheimer's Disease Model Mice |
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| ZHU Hong,DONG Keli,WU Yue,LI Guangcheng,XIAO Lan,ZHANG Ting,WANG Huiling. Effect of Acupuncture for Reinforcing Kidney and Activating Blood on the Neuroglobin Expression in Hippocampus Tissue of Alzheimer's Disease Model Mice[J]. Journal of Traditional Chinese Medicine, 2011, 52(11): 955-957 |
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| Authors: | ZHU Hong DONG Keli WU Yue LI Guangcheng XIAO Lan ZHANG Ting WANG Huiling |
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| Affiliation: | ZHU Hong1,DONG Keli1,WU Yue1,LI Guangcheng1,XIAO Lan1,ZHANG Ting1,WANG Huiling2(1.Xinagya the Third Hospital,Central South University,Changsha 410013,2.Changsha Municipal Mental Disease Hospital) |
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| Abstract: | Objective To investigate the effect and mechanism of acupuncture for reinforcing kidney and activating blood on learning and remembering ability of senescence-accelerated mouse P8(SAMP8) models of Alzheimer's disease.Methods Twenty 5-month-old male SAMP8 mice were randomized into two groups,acupuncture treatment group and model control group,10 in each.Another ten 5-month-old male senescence-accelerated mouse/resistance 1(SAMR1) were prepared as normal control group.The acupuncture treatment group was treat... |
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| Keywords: | acupuncture Alzheimer's disease(AD) senescence-accelerated mouse neuroglobin reinforcing kidney and activating blood |
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