| 微血管生成及细胞增殖在宫颈癌发生中的作用 |
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| 引用本文： | 陈雁南,孔红霞. 微血管生成及细胞增殖在宫颈癌发生中的作用[J]. 中国冶金工业医学杂志, 2007, 24(1): 21-22 |
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| 作者姓名： | 陈雁南 孔红霞 |
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| 作者单位： | 郑州大学第三附属医院暨河南省妇幼保健院妇产科,河南郑州,450002 |
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| 摘 要： | 目的:探讨Endoglin及PCNA在宫颈癌的发展中的作用及相互关系。方法:免疫组化SP法检测32例正常宫颈、31例宫颈癌、34例宫颈上皮内瘤样病变中Endoglin和PCNA的表达,并计算出微血管密度(MVD)和增殖指数(PI)。结果:Endoglin及PCNA与宫颈癌的分级和FIGO的临床分期有密切关系。宫颈上皮内瘤样病变程度与MVD和PI表达呈正相关(P<0.05)。宫颈癌的恶性度和FIGO临床分期与MVD、PI呈正相关(P<0.05)。结论:血管形成参与了宫颈癌的发展;Endoglin和PCNA与宫颈癌恶性程度密切相关。
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| 关 键 词： | 血管生成 增殖细胞核抗原 宫颈癌 微血管密度 |
| 文章编号： | 1005-5495（2007）01-0021-02 |
| 收稿时间： | 2006-08-03 |
| 修稿时间： | 2006-11-20 |
Angiogenesis and cell proliferation in the process of cervical cancer. |
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| CHEN Yan-nan,KONG Hong-xia. Angiogenesis and cell proliferation in the process of cervical cancer.[J]. Chinese Medical Journal of Metallurgical Industry, 2007, 24(1): 21-22 |
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| Authors: | CHEN Yan-nan KONG Hong-xia |
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| Affiliation: | Department of gynaecology and obstetrics, The Third Affiliate Hospital of Zhengzhou University ,Zhengzhou 450052 |
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| Abstract: | Objective:To study effect and relationship between endoglin and PCNA in cervical cancer developing.Methods:Endoglin and PCNA were examined with SP immunohistochemistry in 31 cervical cancer,34 cervical intraepithelial neoplasia(CIN)and 32 normal cervix uteri,and microvessel density(MVD)and proliferation index(PI)were calculated.Results:Endoglin and PCNA correlated positively with pathograde and FGIO stage of cervical carcinoma(P<0.05).The grade of malignant of cervical carcinoma correlated positively with clinical stage of FIGO,MVD and PI(P<0.05).Conclusions:Angiopoiesis participate in development of cervical carcinoma;endoglin and PCNA were correlated positively with malignancy degree of cervical carcinoma. |
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| Keywords: | Endoglin Proliferation cell unclear antigen(PCNA) Cervical cancer Microvessel density(MVD) |
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