大鼠胸主动脉血管成形术后管壁ICAM-1的表达

目的　研究血管成形术后再狭窄形成的机制。方法　 30只大鼠随机分为假手术组和球囊损伤组 ,在术后 1,3,7,14d分别处死动物 (n =6 ) ,光学显微镜检测HE染色的主动脉壁横切面的病理改变 ,免疫组化染色检测细胞间黏附分子 - 1的表达 ,并应用计算机图像分析系统进行分析。结果　球囊损伤组主动脉壁中膜和新生内膜细胞间黏附分子 - 1有高度表达。结论　细胞间黏附分子 - 1参与了血管成形术后再狭窄的发生、发展过程。

Expression of intercellular adhesion molecule-1 in aorta walls of angioplasty rats

Objective To study the mechanism of restenosis of aorta after balloon injury. Methods Thirty Wistar rats were divided into false and balloon injury groups randomly. At days 1, 3, 7 and 14 after injury, rats(n=6) was killed and the target vascular section was isolated and stained with HE to study the pathology changes. Immunohistochemistry was used to detect ICAM-1 expression in aorta vessel and computer image analysis was used to detect the degree of expression about ICAM-1. Results At day 14, the expression of ICAM-1 in intima area was higher in balloon injury group than in false group, while in lumen area was lower in balloon injury group than false group. The expression of ICAM-1 in aorta vessel was higher in balloon injury group than in false group. Conclusion ICAM-1 is involved in the development of restenosis.