Urinary output of endogenous monoamine oxidase inhibitor and isatin during acute migraine attacks |
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Authors: | J Jarman A Przyborowska V Glover J Halket P T G Davies F Clifford Rose M Sandler |
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Institution: | (1) Present address: Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK;(2) The Princess Margaret Migraine Clinic, Charing Cross Hospital, London, UK |
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Abstract: | Summary Urinary output of endogenous monoamine oxidase (MAO) inhibitory activity, was significantly raised in serial samples collected across a migraine attack compared with collections during attack-free periods and in healthy controls, which did not differ from each other. There was a highly significant correlation in output between isatin, a major fraction of the MAO inhibitory activity, and output of the MAO inhibitory activity itself. However, although there was a tendency towards increased isatin excretion during migraine attacks, it failed to reach statistical significance. |
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Keywords: | Monoamine oxidase tribulin isatin migraine |
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