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| 香青兰总黄酮HPMC骨架片释放度的影响因素考察 | |
| 引用本文： | 杨秀,邢建国,王新春,薛桂蓬,马祖文,任文东. 香青兰总黄酮HPMC骨架片释放度的影响因素考察[J]. 中国实验方剂学杂志, 2010, 16(18): 6-9 |
| 作者姓名： | 杨秀 邢建国 王新春 薛桂蓬 马祖文 任文东 |
| 作者单位： | 1. 石河子大学药学院,新疆,石河子,832000 2. 新疆维吾尔自治区药物研究所,乌鲁木齐,830004 3. 石河子大学药学院,新疆,石河子,832000;石河子大学医学院一附院,新疆,石河子,832008 |
| 基金项目： | 国家科技重大专项课题新药创制(2009ZX09103-448) |
| 摘 要： | 目的:制备香青兰总黄酮HPMC(羟丙甲纤维素)骨架片,考察主要活性成分田薊苷体外释药的影响因素。方法:以HPMC为缓释骨架材料,采用湿法制粒压片法制备香青兰总黄酮骨架缓释片;测定香青兰总黄酮HPMC骨架片中主成分田薊苷在不同时间点的释放度,通过对体外释放曲线2,6,12 h累积释放度的综合评分K值及释放曲线相似因子f2的综合比较,考察影响田薊苷体外释药的因素。结果:骨架材料HPMC的种类及乳糖和淀粉的比例是影响田薊苷体外释放的主要因素。骨架材料HPMC的用量及粘合剂等因素对田薊苷释放的影响不大。结论:HPMC K15M能有效控制香青兰总黄酮缓释骨架片中主成分的释放。 |
| 关 键 词： | 香青兰总黄酮 缓释片 释放度 羟丙甲纤维素 |
| 收稿时间： | 2010-07-31 |
Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets |
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| YANG Xiu,XING Jian-guo,WANG Xin-chun,XUE Gui-peng,MA Zu-wen and REN Wen-dong. Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(18): 6-9 | |
| Authors: | YANG Xiu XING Jian-guo WANG Xin-chun XUE Gui-peng MA Zu-wen REN Wen-dong |
| Affiliation: | School of Pharmacy, Shihezi University, Shihezi 832000, China;Xinjiang Institute of Meteria, Urumqi 830004, China;School of Pharmacy, Shihezi University, Shihezi 832000, China;The First Affiliated Hospital of Medical College, Shihezi 832008, China;Xinjiang Institute of Meteria, Urumqi 830004, China;School of Pharmacy, Shihezi University, Shihezi 832000, China;School of Pharmacy, Shihezi University, Shihezi 832000, China |
| Abstract: | Objective: Total flavones sustained-release tablets of Dracocephalum were prepared and the influencing factors on release of the tilianin of Dracocephalum were studied . Method: The Dracocephalum total flavones sustained-release tablets were compressed after wet granulating the extracts of Dracocephalum total flavones with HPMC. Then, the influencing factors on release of tilianin were investigated by determining release-rate of tilianin at different time to draw release curve and calculate K value (a kind of index comprehended with cumulative release at 2, 6, 12 h, respectively) and f2 (similar factorof release curve). Result : The main influencing factors on release-rate of tilianin were the type of HPMC and the ratio of starch to lactose; the amount of HPMC and adhesive were the secondary. Conclusion : The release of tilianin of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices. |
| Keywords: | Dracocephalum total flavones sustained-release tablets HPMC in vitro dissolution |
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