血浆肾上腺髓质素和尾加压素Ⅱ动态变化在毛细支气管炎中的临床意义 |
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引用本文: | 陈啸洪,;周国忠,;夏云,;李华浚,;张佩红,;陈青春.血浆肾上腺髓质素和尾加压素Ⅱ动态变化在毛细支气管炎中的临床意义[J].中华临床感染病杂志,2009(5):273-276. |
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作者姓名: | 陈啸洪 ;周国忠 ;夏云 ;李华浚 ;张佩红 ;陈青春 |
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作者单位: | [1]绍兴市人民医院儿科,312000; [2]绍兴市人民医院分子生物中心,312000; [3]广东省药学院流行病学教研室,312000; |
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摘 要: | 目的探讨毛细支气管炎患儿急性期和恢复期血浆肾上腺髓质素(ADM)及尾加压素Ⅱ(U-Ⅱ)变化的临床意义。方法选择153例毛细支气管炎患儿和36名健康对照儿童,测定患儿急性期(病程〈7d)及恢复期(病程〉14d)血浆ADM和U—Ⅱ水平,分析与疾病症状评分的相关性。结果患儿急性期血浆ADM和U—Ⅱ水平均高于恢复期和健康对照儿童(血浆ADM:t=20.57和26.26,P〈O.01;血浆U—Ⅱ:t=14.27和7.61,P〈0.01),且疾病不同严重程度患儿间也存在明显差异(F=245.94和304.79,P值均〈0.01)。恢复期患儿血浆U-Ⅱ水平低于健康对照儿童(t=6.99,P〈0.01),但ADM水平仍高于对照组(t=8.98,P〈0.01),疾病不同严重程度患儿间血浆ADM水平相近(F=2.25,P〉0.05),而U-Ⅱ水平比较则差异具有统计学意义(F=25.69,P〈0.01)。毛细支气管炎患儿急性期症状评分与血浆ADM和U-Ⅱ水平呈正相关(r值分别为0.884和0.943,P值均为0.000);恢复期症状评分与血浆ADM和U-Ⅱ水平虽在统计学上P值小于0.05,但相关系数较小,因此实际意义不大。结论毛细支气管炎患儿急性期血浆ADM和u-Ⅱ均显著升高,水平与患者病情呈正相关,提示ADM和U-Ⅱ参与了毛细支气管炎的发病,可作为毛细支气管炎严重程度的参考指标之一。
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关 键 词: | 细支气管炎 肾上腺髓质素 尾加压素Ⅱ 症状评分 |
Plasma adrenomedullin and urotensin II concentrations in children with capillary bronchitis |
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Institution: | CHEN Xiao-hong , ZHOU Guo-zhong, XIA Yun, LI Hua-jun, ZHANG Pei-hong, CHEN Qing-chun. ( Department of Pediatrics, the People' s Hospital of Shaoxing, Shaoxing 312000, China) |
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Abstract: | Objective To evaluate the plasma levels of adrenomedullin (ADM) and urotensin Ⅱ ( U- Ⅱ ) in children with capillary bronchiolitis, and their clinical significance. Methods One hundred and fifty three children with capillary bronchiolitis and 36 healthy children were recruited. Plasma levels of ADM and U-l] were measured at acute stage ( 〈 7 days) and convalescent stage ( 〉 14 days) of airway inflammation. The relationship of plasma ADM and U- Ⅱ levels with symptom scores was evaluated. Results Plasma levels of ADM and U-Ⅱ in acute stage of capillary bronchiolitis were significantly higher than those in convalescent stage and healthy controls ( ADM : t = 20. 57 and 26. 26, P 〈 0. 01 ; U- Ⅱ : t = 14. 27 and 7. 61, P 〈 0. 01 ), and there were significant differences among mild, moderate and severe capillary bronchiolitis ( F = 245.94 and 304.79, P 〈 0.01 ). Plasma level of U- Ⅱ in convalescent stage of capillary bronchiolitis was lower than that of healthy controls ( t = 6. 99, P 〈 0. 01 ), but ADM was still in a higher level ( t = 8. 98, P 〈 0.01 ). In the convalescent stage, there was significant difference on U- Ⅱ levels among mild, moderate and severe capillary bronchiolitis (F = 25.69, P 〈 0.01 ), but no significant difference was observed for ADM levels ( F = 2. 25, P 〉 0. 05 ). Plasma levels of ADM and U-Ⅱ in acute stage showed positive correlation with symptom scores, and the regression coefficients were 0. 884 ( P = 0. 000 ) for ADM and 0. 943 ( P= 0. 000 ) for U- Ⅱ. Conclusion Plasma ADM and U-Ⅱ levels in children with capillary bronehiolitis are increased in acute stage and correlated with the symptom scores, which may serve as laboratory indicators for assessing the severity of the disease. |
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Keywords: | Bronchiolitis Adrenomedullin Urotensin Ⅱ Symptom scores |
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