Does somatostatin in the gut inhibit the GLI release locally? |
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Authors: | Seiki Ito Motsuko Hayashi Akira Shibata Yoichi Matsubara |
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Institution: | (1) Department of Surgery, Niigata University School of Medicine, Niigata;(2) First Department of Interral Medicine, Niigata University School of Medicine, 1-Asahimachi, Niigata, Japan |
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Abstract: | Summary Based on the assumption that somatostatin may inhibit peptide release through junctional complexes or through local circulation,
an immunofluorescent technique for somatostatin and GLI in the gut was applied in order to investigate whether suppression
of GLI release by i.v. administration of somatostatin was a physiological effect of somatostatin or not. Somatostatin-immunoreactive
cells (GIF-cells) in the human and canine intestine had no direct cellular contacts with GLI-immunoreactive cells (GLI-cells).
This finding suggests that somatostatin in the intestine does not inhibit GLI release through junctional complexes between
GIF- and GLI-cells. As to the local circulation, most of GIF-cells in the canine intestine were distributed in the deeper
portion of the intestinal gland which corresponds to the upstream sides of the local blood supply of the intestinal gland,
as reported byReynold et al. The ratio of GIF-cells to total cells (GIF-cells + GLI-cells) was 68% in the duodenum and 25% in the ileum. In contrast,
a limited number of GIF-cells was found in the human duodenum where a few GLI-cells were distributed and a few GIF-cells were
seen in the human ileum where a large number of GLI-cells were located. Findings in the dog suggest the possibility that somatostatin
inhibits GLI release from GLI-cells through the local circulation system of intestinal glands. However, findings in humans
suggest that the same possibility does not apply to the human gut. Differences of population density of intestinal GIF-cells
between humans and dogs indicate that the functional meaning of GIF-cells may vary from one species to another.
GLI = glucagon like immunoreactivity. |
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Keywords: | GLI Functional interaction Immunofluorescence Somatostatin |
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