口服美沙酮治疗重度癌痛临床观察

目的观察口服美沙酮治疗重度癌痛使用剂量及不良反应.方法 120例重度癌痛患者分为3组,采用美沙酮直接给药、口服吗啡片滴定后转换为美沙酮、美沙酮联合其他强阿片类药物三种给药方法,分别记录药物使用剂量、疼痛缓解度及不良反应等.结果 120例疼痛总缓解率为92.5%,对骨转移痛有较好疗效,无严重不良反应发生.3组治疗效果基本一致,但美沙酮直接给药时,剂量增加范围较大,不良反应发生率较高.结论美沙酮可有效控制重度癌痛,安全性较好,在其他强阿片类药物治疗效果不满意时,可考虑美沙酮治疗.

Clinical observation on oral methadone for severe cancer pain

Objective To investigate treatment efficacy,using dosage and adverse reaction.120 patients with severe cancer pain were divided into 3 groups,applied 3 administration schemes as direct administration of methadone,oral morphia titration before methadone and methadone combined with other strong opieid.Using dosage,lenitive rate and adverse reaction of medicine were recorded respectively.Results Total lenitive rate was(92.5%) for 120 cases,better result for relieving bone pain caused by bone metastases and no bad reaction accured.Treatment result was basicly the same for 3 groups.But there was higher adverse reaction rate caused by larger dosage when using direct methadone.Conclusion Methadone can effectively control severe cancer pain in safety.When treatment result of other strong opieid is unsatisfied,methadone is a good choice.