Modulation of the Immune Response by Plasma Protease Inhibitors |
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| Authors: | P. GRAVAGNA E. GIANAZZA P. ARNAUD M. NEELS E. W. ADES |
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| Affiliation: | Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA |
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| Abstract: | In two different cytolytic assays, dose-dependent inhibition of antibody-dependent cell-mediated cytotoxicity and natural killing by alpha 2-macroglobulin (alpha 2m) and its subunits was observed. Alpha 2m subunits were approximately four times more inhibitory in both assays than the native alpha 2m molecule on a molar basis. Analysis of trypsin protein esterase activity demonstrated that alpha 2 subunits were four times more active than the parent molecule. |
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