血脂异常与急性脑梗死相关性的临床研究

目的探讨血脂异常与急性脑梗死的相关性。方法收集浙江省中医院2009年10月～2011年10月收治的急性脑梗死患者174例作为观察组,选择同期健康体检者110例作为对照组,比较两组患者的总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）水平,并采用Logistic回归分析与急性脑梗死相关的危险因素。结果①观察组患者TC、LDL-C分别为（4.83±0.10）、（2.83±0.09）mmol/L,明显高于对照组（4.42±0.14）、（2.48±0.12）mmol/L],差异有高度统计学意义（P〈0.01）;观察组HDL-C水平（1.46±0.04）mmol/L]低于对照组（1.69±0.11）mmol/L],差异有统计学意义（P〈0.05）;而观察组与对照组TG值（1.71±0.10）mmol/L比（1.50±0.13）mmol/L],差异无统计学意义（P〉0.05）。②观察组患者TC、LDL-C、HDL-C异常值检出率60.34%（105/174）、72.99%（127/174）、50.57%（88/174）]显著高于对照组60.34%（105/174）、72.99%（127/174）、50.57%（88/174）],差异有高度统计学意义（P〈0.01）;TG异常值检出率两组比较,差异无统计学意义（P〉0.05）。③Logistic回归分析表明,TC、LDL-C、HDL-C均与急性脑梗死发生相关（P〈0.01）。结论 TC、LDL-C、HDL-C异常与急性脑梗死发生密切相关,HDL-C水平降低是急性脑梗死的敏感指标。

Study on the correlation between dyslipidemias and occurrence of acute cerebral infarction

Objective To investigate the relationship between dyslipidemia and occurrence of acute cerebral infarction.Methods 174 cases of acute cerebral infarction admitted to Traditional Chinese Medical Hospital of Zhejiang Province from October 2009 to October 2011 were selected as observation group and 110 cases of healthy people in the same period were chosen as control group.The serum levels of total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C） and triglyceride（TG） between the two groups were compared.Multiple Logistic regression analysis of acute cerebral infarction was applied to conduct the risk assessment.Results ①TC,LDL-C in observation group were（4.83±0.10） mmol/L and（2.83±0.09） mmol/L respectively,they all higher than those in control group （4.42±0.14）,（2.48±0.12） mmol/L],the differences were statistically significant（P ＆lt; 0.01）;the level of HDL-C in observation group （1.46±0.04） mmol/L] was lower than that in control group （1.69±0.11） mmol/ L],the difference was statistically significant（P ＆lt; 0.05）;the difference of TG in the two groups was not statistically significant （1.71±0.10）mmol/L vs（1.50±0.13）mmol/L]（P ＆gt; 0.05）.②The detection rates of abnormal of TC,LDL-C and HDL-C in observation group 60.34%（105/174）,72.99%（127/174）,50.57%（88/174）] were higher than those in control group 60.34%（105/174）,72.99%（127/174）,50.57%（88/174）],the differences were statistically significant（P ＆lt; 0.01）;the difference of detection rates of abnormal of TG was not statistically significant（P ＆gt; 0.05）.③TC,LDL-C and HDL-C levels were important risk factors in acute cerebral infarction according to the Logistic regression analysis.Conclusion The abnormal levels of TC,LDL-C,HDL-C have intimate correlation with the occurrence of acute cere bral infarction.The decline of HDL-C is the sensitive index of acute cerebral infarction.