| 大黄治疗慢性肾功能衰竭有效成分研究 |
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| 引用本文： | 翁涛,潘源虎,游菲. 大黄治疗慢性肾功能衰竭有效成分研究[J]. 时珍国医国药, 2007, 18(6): 1427-1428 |
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| 作者姓名： | 翁涛 潘源虎 游菲 |
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| 作者单位： | 1. 武汉生物工程学院,湖北,武汉,430415
2. 湖北中医学院药学院,湖北,武汉,430065 |
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| 摘 要： | 目的对药用大黄治疗慢性肾功能衰竭的化学成分进行研究。方法应用色谱和光谱技术提取分离和鉴定大黄中化学成分(-)-ep igallocatech in-3-o-gallate(EGCG),并通过口服给予对肾切除致肾衰鼠模型治疗,观察各组动物尿素氮和血肌酐含量。结果EGCG能减低肾衰鼠模型血中尿素氮和血清肌酐水平、降低肾小球膜损伤指数,且与药剂量呈一定量-效关系。结论药用大黄中化学成分EGCG能使肾的组织结构和生理功能接近正常。
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| 关 键 词： | 大黄 肾衰竭 化学成分 |
| 文章编号： | 1008-0805（2007）06-1427-02 |
| 收稿时间： | 2006-11-28 |
| 修稿时间： | 2006-11-282007-01-12 |
Study on the Chemical Constituent of Rhubarb in the Treatment of Chronic Renal Failure |
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| WENG Tao,PAN Yuan-hu,YOU Fei. Study on the Chemical Constituent of Rhubarb in the Treatment of Chronic Renal Failure[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(6): 1427-1428 |
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| Authors: | WENG Tao PAN Yuan-hu YOU Fei |
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| Affiliation: | 1. Wuhan Bioengineering College, Wuhan 430415, China; 2. Hubei College of Traditional Chinese Medicine, Wuhan 430065, China |
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| Abstract: | Objective To study the chemical constituent of rhubarb in the treatment of chronic renal failure.Methods Chromatographic and spectral technologies were used to extract,separate and elucidate the chemical constituent EGCG.Treat the kidney in the mouse model through giving orally,observes each group of animal urea nitrogen and the serum myo-anhydride content.Results The level of urea nitrogen in the blood and serum myo-anhydride decrease.EGCG reducd the renal glomerulus's membrane damage index.Conclusion The chemical constituent EGCG of rhubarb can protect and repair the kidney organic function. |
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| Keywords: | Medical rhubarb Kidney failure Chemical compostion |
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