Bioactive polymers: in vitro and in vivo study of controlled release neomycin. |
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| Authors: | S Dumitriu M Dumitriu S M Dimitriu T Turcu L Grigore D Dumitriu M Iacob |
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| Affiliation: | Polytechnic Institute of Jassy, Department of Macromolecular Chemistry, Romania. |
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| Abstract: | Neomycin is coupled on xanthan-a polysaccharide of microbial biosynthesis produced by Xanthomonas campestris-through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A controlled release of neomycin, following a zero order kinetics is observed, regardless of the eluent flow. Neomycin complexed on xanthan, administered in a unique daily dose to patients suffering from dysentery in the 100 cases taken in study, has shown a high clinical efficiency as compared with the treatments with ampicillin or furazolidone, administered for 5-10 days or longer. |
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