| 肺炎链球菌毒力蛋白在侵入性感染中的免疫原性评价 |
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| 引用本文： | 马千里,张巧,李琦,姚伟,谢晓珍,王长征. 肺炎链球菌毒力蛋白在侵入性感染中的免疫原性评价[J]. 免疫学杂志, 2010, 0(2) |
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| 作者姓名： | 马千里 张巧 李琦 姚伟 谢晓珍 王长征 |
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| 作者单位： | 第三军医大学第二附属医院全军呼吸内科研究所; |
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| 摘 要： | 目的观察肺炎链球菌表面蛋白A(PspA)、肺炎链球菌表面黏附素A(PsaA)及肺炎链球菌溶菌素(Ply)激发自然途径感染肺炎链球菌机体保护性体液免疫应答的情况,评价这三种毒力蛋白作为治疗性肺炎链球菌疫苗候选抗原的免疫原性。方法采集侵入性肺炎链球菌感染患者(实验组)及同期确诊为侵入性其它细菌感染患者(对照第一组)和同期确诊为非感染性疾病患者(对照第二组)各36例急性期(第0+3天)及恢复期(第21±3天)血清样本,酶联免疫吸附法(ELISA)检测患者血清中肺炎链球菌3种毒力蛋白抗原特异性抗体IgG水平变化。结果实验组与两组对照组间第(0+3)天血清的3种肺炎链球菌毒力蛋白特异性抗体水平无显著性差异(P>0.05)。第一组对照组恢复期较急性期血清中3种毒力蛋白特异性抗体水平无显著变化(P>0.05),而实验组恢复期血清3种肺炎链球菌毒力蛋白特异性抗体水平明显高于急性期血清抗体水平8～30倍(P<0.01),其中PspA和Ply蛋白抗原特异性抗体水平升高更明显,血清中针对PspA家族1(PspA-Faml)特异性抗体水平高于针对PspA家族2(PspA-Fam2)的特异性抗体水平(P<0.01)。结论 PsaA,P...
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| 关 键 词： | 肺炎链球菌 肺炎链球菌表面蛋白A 肺炎链球菌表面黏附素A 肺炎链球菌溶菌素 免疫原性 |
Study of immunogenicity of PspA,Ply and PsaA in adults with invasive pneumococcal disease |
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| MA Qianli,ZHANG Qiao,LI Qi,YAO Wei,XIE Xiaozheng,WANG Changzheng Institute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing ,China. Study of immunogenicity of PspA,Ply and PsaA in adults with invasive pneumococcal disease[J]. Immunological Journal, 2010, 0(2) |
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| Authors: | MA Qianli ZHANG Qiao LI Qi YAO Wei XIE Xiaozheng WANG Changzheng Institute of Respiratory Diseases Xinqiao Hospital Third Military Medical University Chongqing China |
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| Affiliation: | MA Qianli,ZHANG Qiao,LI Qi,YAO Wei,XIE Xiaozheng,WANG Changzheng Institute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China |
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| Abstract: | To investigate antibody responses to three Streptococcus pneumoniae surface proteins.PspA,Ply,and PsaA,in adults with invasive pneumococcal disease(IPD),in consideration of taking the three proteins as candidate antigens of Streptococcus pneumoniae vaccine.We characterized antibody responses to PspA,Ply and PsaA,in 36 adults hospitalized with IPD,and in two groups of age-matched controls(group 1:36 patients with invasive disease due to other microorganisms and group 2:36 patients hospitalized for non infect... |
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| Keywords: | Streptococcus pneumoniae PsaA Ply PspA Immunogenicity |
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