Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents |
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| Affiliation: | 1. Department of Clinical Psychology, Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Centre, Shanghai Clinical Centre for Mental Disorders, Shanghai, China;2. Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China;3. Department of Psychiatry, University of California, San Diego, CA, USA;4. Department of Adult Psychiatry, Castle Peak Hospital, Hong Kong, China;5. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China;6. Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiaotong University, Shanghai, China;1. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany;2. Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King''s College London, United Kingdom;3. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland;4. University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246 Hamburg, Germany;5. Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King''s College London, United Kingdom;6. Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany;7. Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany;8. NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France;9. Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, VT, USA;10. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom;11. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany;12. Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany;13. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Sorbonne Paris Cité, and Maison de Solenn, Paris, France;14. AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France;15. Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario M6A 2E1, Canada;p. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany;q. Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria;r. Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany;s. School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland;t. Max Planck Institute for Human Development, Berlin, Germany;u. University Medical Center Hamburg-Eppendorf (UKE), Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany |
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| Abstract: | BackgroundBinge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB.MethodsThe study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172).ResultsAt baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers.ConclusionsGreater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes. |
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| Keywords: | Binge eating Biomarkers Eating disorders Inhibitory control Neuroimaging Stop signal task |
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