When Environment Meets Genetics: A Clinical Review of the Epigenetics of Pain,Psychological Factors,and Physical Activity |
| |
| Affiliation: | 1. Pain in Motion International Research Group, Brussels, Belgium;2. Department of Physiotherapy, Human Physiology and Anatomy, Rehabilitation Sciences and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium;3. Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium;4. Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium;5. External Service for Prevention and Protection at Work, IDEWE, Heverlee, Belgium;1. Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil;2. Programa de Pós Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, RS, Brazil;3. Cellular and Molecular Immunology Lab., Department of Health Basic Sciences,Universidade Federal de Ciências da Saúde de Porto Alegre, RS, Brazil;4. Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil;5. Médico responsável pelo Serviço de Reabilitação Pulmonar do Pavilhão Pereira Filho do Hospital Santa Casa de Misericórdia de Porto Alegre, RS, Brazil;1. Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile;2. Neural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK;3. Chronic Pain Research Group, Division of Population Health and Genomics, Mackenzie Building, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK;4. The Jackson Laboratory, Bar Harbor, ME, USA;5. Department of Clinical Medicine, Danish Pain Research Center, Aarhus University, Aarhus 8000, Denmark;6. Department of Anesthesiology, Perioperative Medicine and Pain Management, and John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA;7. Dr. John and Anne Chong Lab for Functional Genomics, Camperdown, University of Sydney, Sydney, NSW, Australia;8. Departments of Anesthesia and Neurobiology, Children’s Hospital Boston and Harvard Medical School, Boston, MA, USA;2. Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada;3. Krembil Research Institute, University Health Network, Toronto, ON, Canada;4. Department of Surgery, Faculty of Medicine, University of Toronto, ON, Canada;6. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada |
| |
| Abstract: | Epigenetic mechanisms represent a link between the environment and gene function. Recent research shows how early life stress, inflammation, and physical activity can influence gene expression through epigenetic mechanisms. Epigenetic changes—such as DNA methylation and microRNA interference—can be measured in humans and might soon become important biological markers. Epigenetic marks can accompany clinical assessment to measure the effectiveness of various interventions, such as exercise therapy. In addition, epigenetics is improving the understanding of important underlying mechanisms related to the central nervous system, the opioidergic system, and stress responses. Epigenetics is closing a gap in our explanatory abilities and should be implemented to broaden the field of rehabilitation sciences, promote a mechanism-based clinical reasoning, and develop new treatments. In the present review, we focused on epigenetic mechanisms related to pain, psychological factors (such as fear and anxiety), and physical activity, translating relevant findings from these 3 different, yet related, areas of cardinal importance for clinicians. |
| |
| Keywords: | Epigenomics Exercise Methylation Pain Rehabilitation BDNF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" brain-derived neurotrophic factor CNS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" central nervous system HDAC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" histone deacetylase HPA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" hypothalamic-pituitary-adrenal miRNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" microRNA ncRNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" noncoding RNA NR3C1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" nuclear receptor subfamily 3 group C member 1 OPRM1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" μ-opioid receptor-1 TRPV1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" transient receptor potential vanilloid 1 TRPA1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" transient receptor potential ankyrin 1 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
