| 鸦胆子苦醇调节Nrf2/SLC7A11/GPX4信号通路对皮肤鳞癌细胞铁死亡的影响 |
| |
| 引用本文： | 谌程程,何平,黄宇婧,陈爱军. 鸦胆子苦醇调节Nrf2/SLC7A11/GPX4信号通路对皮肤鳞癌细胞铁死亡的影响[J]. 重庆医科大学学报, 2023, 48(4): 369-374 |
| |
| 作者姓名： | 谌程程 何平 黄宇婧 陈爱军 |
| |
| 作者单位： | 1.重庆医科大学附属第一医院皮肤科，重庆 400016;2.陆军军医大学新桥医院整形美容科，重庆 400042 |
| |
| 摘 要： | 目的：探讨鸦胆子苦醇调节核因子E2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)/溶质载体家族7成员11(solute carrier family 7 member 11,SLC7A11)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)信号通路对皮肤鳞癌（cutaneous squamous cell carcinoma,cSCC）细胞铁死亡的影响。方法：CCK-8法检测0、100、250、500、700、900 nmol/L鸦胆子苦醇处理后人cSCC细胞系A431细胞增殖率，筛选出合适的鸦胆子苦醇作用浓度。体外培养的A431细胞随机分为对照组、鸦胆子苦醇低剂量组、鸦胆子苦醇高剂量组、特丁基对苯二酚（tert-butylhydroquinone,TBHQ;Nrf2激活剂）组、鸦胆子苦醇高剂量+TBHQ组，以鸦胆子苦醇和TBHQ分组处理后，采用CCK-8法、Hoechst 33342染色法检测各组A431细胞增殖与凋亡；采用试剂盒检测各组A431细胞抗氧化因子[谷胱甘肽（glutathi...
|
| 关 键 词： | 鸦胆子苦醇 核因子E2相关因子2/溶质载体家族7成员11/谷胱甘肽过氧化物酶4 皮肤鳞癌 铁死亡 |
| 收稿时间： | 2022-08-27 |
Influence of brusatol on ferroptosis in cutaneous squamous cell carcinoma cells by regulating Nrf2/SLC7A11/GPX4 signaling pathway |
| |
| Chen Chengcheng,He Ping,Huang Yujing,Chen Aijun. Influence of brusatol on ferroptosis in cutaneous squamous cell carcinoma cells by regulating Nrf2/SLC7A11/GPX4 signaling pathway[J]. Journal of Chongqing Medical University, 2023, 48(4): 369-374 |
| |
| Authors: | Chen Chengcheng He Ping Huang Yujing Chen Aijun |
| |
| Affiliation: | 1.Department of Dermatology,The First Affiliated Hospital of Chongqing Medical University;2.Department of Plastic Surgery,Xinqiao Hospital,Army Medical University |
| |
| Abstract: | |
| |
| Keywords: | brusatol nuclear factor erythroid-2 related factor 2/solute carrier family 7 member 11/glutathione peroxidase 4 cutaneous squamous cell carcinoma ferroptosis |
|
| 点击此处可从《重庆医科大学学报》浏览原始摘要信息 |
|
点击此处可从《重庆医科大学学报》下载全文 |
